The gene for serine tRNA having anticodon sequence CAG in a pathogenic yeast, Candida albicans.
نویسندگان
چکیده
Tsutomu Suzuki, Takuya Ueda*, Takeshi Ohama + , Syozo Osawa and Kimitsuna Watanabe Department of Biological Sciences, Faculty of Bioscience and Biotechnology, Tokyo Institute of Technology, Nagatsuta 4259, Midori-ku, Yokohama 227, 1 Department of Industrial Chemistry, Faculty of Engineering, University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113 and Department of Biology, School of Science, Nagoya University, Chikusa-ku, Nagoya 464-01, Japan
منابع مشابه
Serine tRNA complementary to the nonuniversal serine codon CUG in Candida cylindracea: evolutionary implications.
In the asporogenic yeast Candida cylindracea, the codon CUG is read as serine instead of leucine. This is an unusual instance in which the amino acid assignment of a codon deviates from the universal code. To infer the evolutionary process of this change, the tRNA with the anticodon sequence CAG, which is complementary to and thus responsible for translation of the codon CUG, has been identifie...
متن کاملCharacterization of serine and leucine tRNAs in an asporogenic yeast Candida cylindracea and evolutionary implications of genes for tRNACAG responsible for translation of a non-universal genetic code
Five serine and three leucine isoacceptor tRNAs were purified from the asporogenic yeast Candida cylindracea, in which codon CUG is translated as serine Instead of leucine [1], and their primary structures were determined. From the wobble hypothesis [2], it was assumed that one of the tRNA species (Leu1), with the antlcodon CmAA, corresponded to the UUG leucine codon, and that the remaining two...
متن کاملComparative evolutionary genomics unveils the molecular mechanism of reassignment of the CTG codon in Candida spp.
Using the (near) complete genome sequences of the yeasts Candida albicans, Saccharomyces cerevisiae, and Schizosaccharomyces pombe, we address the evolution of a unique genetic code change, which involves decoding of the standard leucine-CTG codon as serine in Candida spp. By using two complementary comparative genomics approaches, we have been able to shed new light on both the origin of the n...
متن کاملA Genetic Code Alteration Is a Phenotype Diversity Generator in the Human Pathogen Candida albicans
BACKGROUND The discovery of genetic code alterations and expansions in both prokaryotes and eukaryotes abolished the hypothesis of a frozen and universal genetic code and exposed unanticipated flexibility in codon and amino acid assignments. It is now clear that codon identity alterations involve sense and non-sense codons and can occur in organisms with complex genomes and proteomes. However, ...
متن کاملThe 'polysemous' codon--a codon with multiple amino acid assignment caused by dual specificity of tRNA identity.
In some Candida species, the universal CUG leucine codon is translated as serine. However, in most cases, the serine tRNAs responsible for this non-universal decoding (tRNA(Ser)CAG) accept in vitro not only serine, but also, to some extent, leucine. Nucleotide replacement experiments indicated that m1G37 is critical for leucylation activity. This finding was supported by the fact that the tRNA(...
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ورودعنوان ژورنال:
- Nucleic acids research
دوره 21 2 شماره
صفحات -
تاریخ انتشار 1993